Yes. There are several organizations and groups which can help refugees to start up their own business.
Moreover, it is always advisable to hire an accountant to handle all the administrative and tax details, so that you can focus on your business.
A good start point is project MEnt (Migrant Entrapreneurs team-up with mentors) site: https://www.mentproject.eu
If you plan to start a venture which may have a relevant social, cultural and/or environmental value, you cold join Make a Cube3 : https://makeacube.com
Other information can be found at the local Chamber of Commerce https://www.cameradicommercio.it